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1

Phosphorothioate Nucleotides and Oligonucleotides – Recent Progress in Synthesis and Application

Piotr Guga, Maria Koziołkiewicz

Journal:

Chemistry & Biodiversity

Year:

2011

Language:

english

File:

PDF, 445 KB

english, 2011

2

An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective

Jayaram, Makkuni, Rowley, Paul A, Fan, Hsui-Fang, Kachroo, Aashiq H, Voziyanov, Yuri, Guga, Piotr, Ma, Chien-Hui

Journal:

Microbiology Spectrum

Year:

2015

Language:

english

File:

PDF, 5.22 MB

english, 2015

3

A Flp-SUMO hybrid recombinase reveals multi-layered copy number control of a selfish DNA element through post-translational modification

Ma, Chien-Hui, Su, Bo-Yu, Maciaszek, Anna, Fan, Hsiu-Fang, Guga, Piotr, Jayaram, Makkuni, Malik, Harmit S.

Journal:

Year:

2019

Language:

english

File:

PDF, 4.87 MB

english, 2019

4

Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

Piotr Guga, Krzysztof Domański, Wojciech J. Stec

Journal:

Angewandte Chemie

Year:

2001

Language:

english

File:

PDF, 101 KB

english, 2001

5

Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

Piotr Guga, Krzysztof Domański, Wojciech J. Stec

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

6

Recent Advances in Stereocontrolled Synthesis of P-Chiral Analogues of Biophosphates.

Piotr Guga, Andrzej Okruszek, Wojciech J. Stec

Journal:

Year:

2002

File:

PDF, 24 KB

2002

7

ChemInform Abstract: Phosphorothioate Nucleotides and Oligonucleotides — Recent Progress in Synthesis and Application

Piotr Guga, Maria Koziolkiewicz

Journal:

Year:

2012

File:

PDF, 18 KB

2012

8

Diastereomerically pure nucleoside-5′-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s—Substrates for synthesis of P-chiral derivatives of nucleoside-5′-O-phosphorothioates

Agnieszka Tomaszewska, Piotr Guga, Wojciech J. Stec

Journal:

Year:

2011

Language:

english

File:

PDF, 234 KB

english, 2011

9

Stereochemistry of the reaction of ribonucleoside cyclic 3′,5′-phosphorothioates with oxiranes

Andrzej Okruszek, Piotr Guga, Wojciech J. Stec

Journal:

Heteroatom Chemistry

Year:

1991

Language:

english

File:

PDF, 643 KB

english, 1991

10

Cyclization versus oligomerization of SP- and RP-5′-OH-N4-benzoyl-2′-deoxycytidine-3′-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s

Piotr Guga, Bolesław Karwowski, Damian Błaziak, Magdalena Janicka, Andrzej Okruszek, Beata Rębowska, Wojciech J. Stec

Journal:

Year:

2006

Language:

english

File:

PDF, 179 KB

english, 2006

11

Stereoretentive conversion of dialkyl phosphorothioates into [18O]-phosphates

Piotr Guga, Wojciech J. Stec

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 196 KB

english, 1983

12

Stereoretentive conversion of dialkyl [18O]-phosphoranilidates into dialkyl hydrogen [18O]-phosphates

Piotr Guga, Andrzej Wilk, Wojciech J. Stec

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 121 KB

english, 1985

13

Synthesis and absolute configuration of P-chiral O-isopropyl oligonucleotide triesters

Wojciech J. Stec, Gerald Zon, Kathleen A. Gallo, R.Andrew Byrd, Bogdan Uznanski, Piotr Guga

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 306 KB

english, 1985

14

Stereospecific conversion of P-chiral nucleoside phosphorothioates into [18O]phosphates

Piotr Guga, Andrzej Okruszek

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 210 KB

english, 1984

15

Stereochemistry of cleavage of internucleotide bonds by Serratia marcescens endonuclease

Maria Koziołkiewicz, Alina Owczarek, Krzysztof Domañski, Marian Nowak, Piotr Guga, Wojciech J. Stec

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 186 KB

english, 2001

16

Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination

Ma, Chien-Hui, Rowley, Paul A, Macieszak, Anna, Guga, Piotr, Jayaram, Makkuni

Journal:

The EMBO Journal

Year:

2009

Language:

english

File:

PDF, 981 KB

english, 2009

17

The effects of tumor necrosis factor (TNF) derivatives on TNF receptors

Henryk Tchorzewski, Krzysztof Zeman, Ewa Paleolog, Fionula Brennan, Marc Feldmann, Mel Kahan, Piotr Guga, Marek Kwinkowski, Bozena Szymanska, Joanna Jarosz, Pawel Parniewski, Eugeniusz Kocur

Journal:

Year:

1993

Language:

english

File:

PDF, 674 KB

english, 1993

18

Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model

Takubumi Inagawa, Hideki Nakashima, Boleslaw Karwowski, Piotr Guga, Wojciech J. Stec, Hiroaki Takeuchi, Hiroshi Takaku

Journal:

Year:

2002

Language:

english

File:

PDF, 300 KB

english, 2002

19

A Single Nuclease-Resistant Linkage in DNA as a Versatile Tool for the Characterization of DNA Lesions: Application to the Guanine Oxidative Lesion “G+34” Generated by Metalloporphyrin/KHSO 5 Reagent

Tomaszewska, Agnieszka, Mourgues, Sophie, Guga, Piotr, Nawrot, Barbara, Pratviel, Geneviève

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

20

Stereoselective formation of a P–P bond in the reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with O,O-dialkyl H-phosphonates and H-thiophosphonates

Błaziak, Damian, Guga, Piotr, Jagiełło, Agata, Korczyński, Dariusz, Maciaszek, Anna, Nowicka, Anna, Pietkiewicz, Aleksandra, Stec, Wojciech J.

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 275 KB

english, 2010

21

Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition?

Tonelli, Marco, Ulyanov, Nikolai B., Billeci, Todd M., Karwowski, Boleslaw, Guga, Piotr, Stec, Wojciech J., James, Thomas L.

Journal:

Biophysical Journal

Year:

2003

Language:

english

File:

PDF, 466 KB

english, 2003

22

Unusual Thermal Stability of RNA/[RP-PS]-DNA/RNA Triplexes Containing a Homopurine DNA Strand

Guga, Piotr, Boczkowska, Małgorzata, Janicka, Magdalena, Maciaszek, Anna, Kuberski, Sławomir, Stec, Wojciech J.

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 221 KB

english, 2007

23

Hoogsteen-Paired Homopurine [RP-PS]-DNA and Homopyrimidine RNA Strands Form a Thermally Stable Parallel Duplex

Guga, Piotr, Janicka, Magdalena, Maciaszek, Anna, Rębowska, Beata, Nowak, Genowefa

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 165 KB

english, 2007

24

Diastereomers of Nucleoside 3'-O-(2-Thio-1,3,2-oxathia(selena)phospholanes): Building Blocks for Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s

Stec, Wojciech J., Grajkowski, Andrzej, Kobylanska, Anna, Karwowski, Boleslaw, Koziolkiewicz, Maria, Misiura, Konrad, Okruszek, Andrzej, Wilk, Andrzej, Guga, Piotr, Boczkowska, Malgorzata

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 3.07 MB

english, 1995

25

Activation of the Carboxy Terminus of a Peptide for Carboxy-Terminal Sequencing

Boyd, Victoria L., Bozzini, MeriLisa, Guga, Piotr J., DeFranco, Robert J., Yuan, Pau-Miau, Loudon, G. Marc, Nguyen, Duy

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 738 KB

english, 1995

26

Retention of Configuration in the Action of Human Plasma 3‘-Exonuclease on Oligo(deoxynucleoside phosphorothioate). A New Method for Assignment of Absolute Configuration at Phosphorus in Isotopomeric Deoxyadenosine 5‘- O -[ 18 O]Phosphorothioate

Koziołkiewicz, Maria, Owczarek, Alina, Wójcik, Marzena, Domański, Krzysztof, Guga, Piotr, Stec, Wojciech J.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 101 KB

english, 2002

27

Deoxyribonucleoside 3‘- O -(2-Thio- and 2-Oxo-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane)s: Monomers for Stereocontrolled Synthesis of Oligo(deoxyribonucleoside phosphorothioate)s and Chimeric PS/PO Oligonucleotides §

Stec, Wojciech J., Karwowski, Bolesław, Boczkowska, Małgorzata, Guga, Piotr, Koziołkiewicz, Maria, Sochacki, Marek, Wieczorek, Michał W., Błaszczyk, Jarosław

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 323 KB

english, 1998

28

Oxathiaphospholane Approach to the Synthesis of Oligodeoxyribonucleotides Containing Stereodefined Internucleotide Phosphoroselenoate Function †

Guga, Piotr, Maciaszek, Anna, Stec, Wojciech J.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 60 KB

english, 2005

29

DNA-Triesters - The Synthesis and Absolute Configuration Assignments at P-Stereogenic Centres

Guga, Piotr, Koziołkiewicz, Maria, Okruszek, Andrzej, Uznański, Bogdan, Stec, Wojciech J.

Journal:

Nucleosides and Nucleotides

Year:

1987

Language:

english

File:

PDF, 436 KB

english, 1987

30

Stereodefined Phosphorothioate Analogues of DNA: Relative Thermodynamic Stability of the Model PS-DNA/DNA and PS-DNA/RNA Complexes †

Boczkowska, Małgorzata, Guga, Piotr, Stec, Wojciech J.

Journal:

Year:

2002

Language:

english

File:

PDF, 49 KB

english, 2002

31

Effect of P-Chirality of Internucleotide Bonds on B−Z Conversion of Stereodefined Self-Complementary Phosphorothioate Oligonucleotides of the [PS]-d(CG) 4 and [PS]-d(GC) 4 Series †

Boczkowska, Małgorzata, Guga, Piotr, Karwowski, Bolesław, Maciaszek, Anna

Journal:

Year:

2000

Language:

english

File:

PDF, 132 KB

english, 2000

32

Direct transformation of ribonucleoside cyclic 3?,5?-phosphorothioates into cyclic 2?,3?-phosphates

Okruszek, Andrzej, Guga, Piotr, Stec, Wojciech J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1985

Language:

english

File:

PDF, 168 KB

english, 1985

33

Novel approach to the synthesis of isotopomeric monoalkyl [16O,17O,18O]phosphates. The stereospecific one-pot conversion of (R P)-thymidine 3?-(4-nitrophenyl)phosphorothioate into (R P)-thymidine 3?-[16O,17O,18O]phosphate

Okruszek, Andrzej, Guga, Piotr, Stec, Wojciech J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1987

Language:

english

File:

PDF, 211 KB

english, 1987

34

P-Chirality-Dependent Immune Activation by Phosphorothioate CpG Oligodeoxynucleotides

Krieg, Arthur M., Guga, Piotr, Stec, Wojciech

Journal:

Oligonucleotides

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

35

Nucleoside 3′- O -(2-Oxo-“ Spiro ”-4.4-Pentamethylene-1.3.2-Oxathiaphospholane)S: Monomers For Stereocontrolled Synthesis Of Oligo(Nucleoside Phosphorothioate/Phosphate)S

Karwowski, Boleslaw, Guga, Piotr, Kobylariska, Anna, Stec, Wojciech J.

Journal:

Nucleosides and Nucleotides

Year:

1998

Language:

english

File:

PDF, 651 KB

english, 1998

36

Synthesis of P-Chiral [ 18 O]-Labeled Isotopomeric Oligo(deoxyribonucleoside Phosphorothioate)s and Phosphates

Guga, Piotr, Domański, Krzysztof, Koziołkiewicz, Maria, Owczarek, Alina, Stec, Wojciech J.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

2002

Language:

english

File:

PDF, 77 KB

english, 2002

37

Stability of Stereoregular Oligo(nucleoside Phosphorothioate)s in Human Plasma: Diastereoselectivity of Plasma 3‵-Exonuclease

KOZIOŁKIEWICZ, MARIA, WÓJCIK, MARZENA, KOBYLAŃSKA, ANNA, KARWOWSKI, BOLESŁAW, RȨBOWSKA, BEATA, GUGA, PIOTR, STEC, WOJCIECH J.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1997

Language:

english

File:

PDF, 4.76 MB

english, 1997

38

Stereochemistry of Dbu-Assisted Reaction of Nucleoside 3'-O-(2-Thiono-1.3.2-Oxathiaphospholanes) with 5'-Hydroxynucleosides

Stec, Wojciech, Karwowski, Boleslaw, Guga, Piotr, Misiura, Konrad, Wieczorek, Michal, Blaszczyk, Jaroslaw

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1996

Language:

english

File:

PDF, 247 KB

english, 1996

39

LNA units present in the (2′-OMe)-RNA strand stabilize parallel duplexes (2′-OMe)-RNA/[All-R P -PS]-DNA and parallel triplexes (2′-OMe)-RNA/[All-R P -PS]-DNA/RNA. An improved tool for the inhibition of reverse transcription

Maciaszek, Anna, Krakowiak, Agnieszka, Janicka, Magdalena, Tomaszewska-Antczak, Agnieszka, Sobczak, Milena, Mikołajczyk, Barbara, Guga, Piotr

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

40

Unexpected Loss of Stereoselectivity in Ring-Opening Reaction of 2-Alkoxy-2-Thio-1,3,2-Oxathiaphospholanes With a Pyrophosphate Anion

Guga, Piotr, Tomaszewska, Agnieszka

Journal:

Year:

2015

Language:

english

File:

PDF, 711 KB

english, 2015

41

Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent

Benimetskaya, Lyuba, Tonkinson, John L., Koziolkiewicz, Maria, Karwowski, Boleslaw, Guga, Piotr, Zeltser, Ross, Stec, Wojciech, Stein, C.A.

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 6.86 MB

english, 1995

42

P-Chiral Oligonucleotides in Biological Recognition Processes

Journal:

Current Topics in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 432 KB

english, 2007

43

Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices

Jastrzębska, Katarzyna, Maciaszek, Anna, Dolot, Rafał, Bujacz, Grzegorz, Guga, Piotr

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 491 KB

english, 2015

44

Enhanced P-stereodependent stability of complexes formed by phosphorothioate oligonucleotides due to involvement of sulfur as strong hydrogen bond acceptor

Guga, Piotr, Boczkowska, Małgorzata, Janicka, Magdalena, Maciaszek, Anna, Nawrot, Barbara, Antoszczyk, Sławomir, Stec, Wojciech J.

Journal:

Pure & Applied Chemistry

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

45

Stereospecific suppression of active site mutants by methylphosphonate substituted substrates reveals the stereochemical course of site-specific DNA recombination

Rowley, Paul A., Kachroo, Aashiq H., Ma, Chien-Hui, Maciaszek, Anna D., Guga, Piotr, Jayaram, Makkuni

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 9.19 MB

english, 2015

46

Guanosine in a Single Stranded Region of Anticodon Stem-Loop tRNA Models is Prone to Oxidatively Generated Damage Resulting in Dehydroguanidinohydantoin and Spiroiminodihydantoin Lesions

Tomaszewska-Antczak, Agnieszka, Guga, Piotr, Nawrot, Barbara, Pratviel, Geneviève

Journal:

Chemistry - A European Journal

Year:

2015

Language:

english

File:

PDF, 583 KB

english, 2015

47

ChemInform Abstract: Phosphorothioate Nucleotides and Oligonucleotides-Recent Progress in Synthesis and Application

Guga, Piotr, Koziolkiewicz, Maria

Journal:

Year:

2013

File:

PDF, 19 KB

2013

48

1,3,2-Oxathiaphospholane approach to the synthesis of P-chiral stereodefined analogs of oligonucleotides and biologically relevant nucleoside polyphosphates

Nawrot, Barbara, Rębowska, Beata, Michalak, Olga, Bulkowski, Marek, Błaziak, Damian, Guga, Piotr, Stec, Wojciech J.

Journal:

Pure & Applied Chemistry

Year:

2008

Language:

english

File:

PDF, 313 KB

english, 2008

49

P -Stereodefined phosphorothioate analogs of glycol nucleic acids—synthesis and structural properties

Tomaszewska-Antczak, Agnieszka, Jastrzębska, Katarzyna, Maciaszek, Anna, Mikołajczyk, Barbara, Guga, Piotr

Journal:

Year:

2018

File:

PDF, 886 KB

2018

50

P -Stereodefined phosphorothioate analogs of glycol nucleic acids—synthesis and structural properties

Tomaszewska-Antczak, Agnieszka, Jastrzębska, Katarzyna, Maciaszek, Anna, Mikołajczyk, Barbara, Guga, Piotr

Journal:

Year:

2018

Language:

english

File:

PDF, 886 KB

english, 2018

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